Microglia and astrocytes are crucial players in brain pathology. Upon brain injury, they actively influence the outcome of the insult, contributing to protection and recovery or to the disease progression. The functions of glia critically depend on proper sorting of cell surface and secreted molecules, e.g. cytokines. Yet, the mechanisms of activity-dependent protein trafficking in glia remain unexplored. My preliminary data uncovered potential role for VPS10P proteins, primarily recognised as neuronal sorting receptors, in protein trafficking in glia. In particular, I show that the release of interleukin-6 from astrocytes depends on the VPS10P receptor SorCS2. Here, I will further investigate this novel role for VPS10P receptors by analysing their expression in glia and identifying their cargos. Next, I will study the impact of receptor-dependent protein sorting in glia on Devastating brain pathologies, stroke and glioma, which may have important implications for future therapies.