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project info
Start date: 1 November 2018
End date: 29 July 2021
funding
Fund: European Regional Development Fund (ERDF)
Total budget: 177 653,27 €
EU contribution: 177 653,27 € (100%)
programme
Programming period: 2014-2021
Managing authority: Ministerstwo obsługujące ministra właściwego ds. rozwoju regionalnego

Novel cytotoxic conjugates of peptibodies targeting fibroblast growth factor receptors (FGFR)

Fibroblast growth factor receptors (FGFRs) are an emerging target for directed cancer therapy. The aim of this research proposal is to develop a new conjugate aimed at FGFR-expressing cancer cells, based on FGFR-binding peptibody conjugated with a potent cytotoxic drug, monomethylauristatin E (MMAE). New peptides with FGFR-binding properties will be identified within the project and used to construct peptibodies, a promising alternative to monoclonal antibodies. Peptibodies will be then conjugated with MMAE, a cytotoxic drug well-studied for clinical applications, and used as selective delivery vehicles targeting FGFR-expressing cancer cells. These peptibody-drug conjugates May serve as a basis for development of therapy for tumours relying on overexpressed or malfunctioning FGFRs.

Flag of Poland  Trójmiejski, Poland