In a political and societal context of reducing inputs in viticulture and oenology, the BIOVI project offers alternative tools to the chemical inputs of vine and wine, while respecting the production and quality criteria of the products. Thus, the conventional vineyard protection routes and an integrated strategy using SDPs (defense stimulations) against mildew, mildew and grey rot will be compared. This comparison will include health quality, the effectiveness of SDPs in ducating vine defences and, finally, compatibility with the bioprotection of wine. Bioprotection consists of using microorganisms selected for their ability to compete with natural flora, among which microorganisms of alterations. The effectiveness and conditions of use of non Saccharomyces yeasts as a bioprotection tool to reduce the use of inputs and understand the functioning of bioprotection will be studied. To be an alternative to sulphites, bioprotection must be able to replace all or part of the properties of the inputs, namely antioxidant, antioxidant and antimicrobial activity. The antioxidant activity is particularly crucial and the expertise of our team will be used to identify molecular markers involved in antioxidant activity, especially by metabolomics.